Heart risk raised in women regularly using NSAIDs
July 14th 2014Women who are regular users of non-steroidal anti-inflammatory drugs (NSAIDs) should be aware that these medications may increase the risk of adverse cardiovascular events, according to a study published in the July issue of Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.
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Secukinumab clears skin in psoriasis patients: Studies
July 14th 2014Psoriasis patients treated with interleukin-17A (IL-17A) inhibitor secukinumab demonstrated statistically significant skin clearance, according to in 2 pivotal phase 3 studies published in The New England Journal of Medicine.
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Opioid deaths among young adults on the rise
July 14th 2014Rates of opioid overdose in Ontario, Canada, have increased more than 3-fold over the past 2 decades, according to a study online in Addiction. Furthermore, deaths are clustered among younger Ontarians; in 2010, 1 in 8 deaths among those aged 25 to 34 years were related to opioids.
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MI risk not increased in older men receiving testosterone therapy
July 11th 2014Older men treated with intramuscular testosterone did not appear to have an increased risk of myocardial infarction (MI). For men with high MI risk, testosterone use was modestly protective against MI, according to a study published in Annals of Pharmacotherapy
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Class III obesity linked with substantially elevated rates of total mortality: Study
July 11th 2014Otherwise healthy, non-smoking adults with BMI values within the class III obesity range may considerably extend their life expectancy by avoiding additional weight gain, according to a study published in PLOS Medicine.
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Psychiatric drugs responsible for 90,000 ED visits annually
July 11th 2014Adverse reactions to antipsychotics, antidepressants, sedatives and anxiolytics, lithium salts or stimulant drugs are responsible for almost 90,000 emergency department (ED) visits each year by US adults, according to a study in JAMA Psychiatry.
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Death due to opioid overdose rising in United States
July 11th 2014Drug overdose deaths in the United States increased for the 11th consecutive year in 2010, according to an analysis from the Centers for Disease Control and Prevention (CDC) and. continued to rise in 2011, the most recent year for which data were available.
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In adult patients with type 2 diabetes inadequately controlled on metformin monotherapy-the current standard of treatment- canagliflozin (Invokana) 100 mg and 300 mg reduced relative risk for myocardial infarction (1.6% and 3.0%) and congestive heart failure (2.7% and 4.0%), as compared to sitagliptin 100 mg, according to findings of the health economic simulation analysis presented at the American Diabetes Association (ADA) Scientific Sessions in San Francisco.
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[BLOG] Clinical trial collaborations: An idea whose time has come
July 1st 2014The cost and time commitment to develop new drugs has increased significantly over the last few decades. A variety of factors come into play, but on average, in terms of total expenditures, it has taken from $3 to $5 billion and up to 15 years to bring a new drug to market. Even after all that time and money, with challenging regulatory requirements and other factors, the odds of a new compound making it from the lab to the pharmacy are miniscule. The chance for a new drug to make it to market is a sobering 1 in 5000.
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Patients with diabetic macular edema (DME) treated with aflibercept Injection significantly improved vision and reduced the severity of diabetic retinopathy versus laser photocoagulation, according to data recently presented the American Diabetes Association (ADA) Scientific Sessions in San Francisco.
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[BLOG] Blessings in disguise Should formularies welcome premium-priced bladder cancer drugs?
July 1st 2014The management of bladder cancer represents one of the most costly and underestimated challenges in the oncology spectrum. Despite having the 6th highest incidence of any cancer in the United States, high recurrence rates and the need to constantly monitor patients act as the primary drivers for the high expenditures associated with the disease.
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