Advancing Diagnostic Precision in Type 1 Diabetes
July 23rd 2025Panelists discuss how autoantibody testing has high diagnostic accuracy with nearly 100% conversion to hyperglycemia when two or more antibodies are present, though timing of testing is crucial and retesting may be necessary since antibody levels can fluctuate over time.
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National PrEP Program Not Yet a Reality in United States
July 21st 2025A national preexposure prophylaxis (PrEP) program would streamline access and improve HIV outcomes but unfortunately never came to pass because of a lack of funding, according to Jeremiah Johnson, executive director, PrEP4All.
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Future Forward: Advancing SCAC Treatment Through Innovation and Access
July 18th 2025A panelist discusses how the FDA approval and NCCN endorsement of retifanlimab plus carboplatin/paclitaxel represents a milestone that should focus attention on adding PD-1 inhibitors to advanced squamous cell anal carcinoma treatment while highlighting future therapeutic opportunities including combination immunotherapies (PD-L1 with CTLA-4 inhibitors), bispecific antibodies targeting EGFR, cellular therapies targeting human papillomavirus-associated antigens E6/E7, and antibody-drug conjugates, emphasizing the critical need to disseminate this recent level-one evidence to providers and remove insurance barriers to ensure patient access to these important treatments.
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Optimizing Multidisciplinary Care in Vitiligo
July 18th 2025An expert discusses how patients with vitiligo are often initially misdiagnosed by primary care providers as having fungal infections before being referred to dermatologists, with care coordination typically involving endocrinologists for thyroid management and psychologists for mental health support.
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Applying Evidence Standards to Guide Gene Therapy Use in BCG-Unresponsive NMIBC
July 17th 2025An expert discusses how high-cost gene therapies require evidence standards including Phase 3 trial data showing complete response rates and durability, real-world evidence and health economic analyses to guide clinical use and coverage determinations before payers scrutinize their carte blanche approval.
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An expert discusses how recent updates to AUA, EAU and NCCN guidelines have cautiously shifted toward more bladder-sparing approaches for BCG-unresponsive patients, incorporating new FDA-approved therapies as conditional recommendations for those unwilling or unable to undergo radical cystectomy.
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Public Health Expert Warns U.S. HIV Funding Cuts Could Set Back Global Progress | IAS 2025
July 16th 2025Mulugeta Gebregziabher, Ph.D., spoke with Managed Healthcare Executive ahead of his presentation at IAS 2025 in Kigali, Rwanda, about the risks posed by U.S. cuts to global HIV prevention funding.
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Using Data Science to Address HIV Inequities, Region by Region | IAS 2025
July 16th 2025At the IAS 2025 conference in Kigali, Rwanda, Banky Olatosi, M.P.H., M.S., Ph.D., of the University of South Carolina, shed light on how systemic racism and social determinants of health influence HIV diagnoses and care across U.S. regions.
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HIV Self-Testing Significantly Increases Diagnosis and Treatment Initiation, Study Shows | IAS 2025
Published: July 16th 2025 | Updated: July 16th 2025While successes have been seen because of HIV self-testing, funding cuts to USAID and PEPFAR will make continued research difficult, according to Anna Bershteyn, Ph.D., associate professor in the Department of Population Health, NYU Grossman School of Medicine.
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Study Limitations, Clinical Relevance and Diagnostic Implications
July 16th 2025Panelists discuss how to improve diagnostic accuracy through increased awareness and education among healthcare providers, simplifying antibody testing processes and identifying high-risk patients who should be screened for type 1 diabetes, including those with family history or other autoimmune conditions.
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Alarice Marsh, M.P.H., a deputy director in the National Department of Health of South Africa and program lead of HIV testing services, spoke with MHE editors about her thoughts on the new recommendations for HIV and sexually transmitted diseases that were issued by the World Health Organization (WHO) today.
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Empowerment Through PrEP Access is Self-Care | IAS 2025
July 14th 2025There is currently a movement to “de-medicalize" PrEP by pushing for more availability at more casual settings than government clinics, according to Anna Bershteyn, Ph.D., associate professor in the Department of Population Health, NYU Grossman School of Medicine.
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Modern HIV Rapid Test Similar to COVID Rapid Test | IAS 2025
July 13th 2025The most common HIV antibody blood test is called an “A-0” test, which is available for approximately 70 cents in many low- and middle-income countries, according to Anna Bershteyn, Ph.D., associate professor in the Department of Population Health, NYU Grossman School of Medicine.
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How Prior Authorization Reform Could Help Patients and Providers
July 11th 2025In this part three interview of a video series, Hari Prasad, CEO of Yosi Health, told Managed Healthcare Executive editors that cutting administrative burdens through digitized prior authorizations could improve patient outcomes and restore valuable time to physicians.
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AI Can Ease Prior Authorization Burdens if Used Responsibly
July 11th 2025In this part two interview of a three-part video series, Hari Prasad, CEO of Yosi Health, said in an interview with MHE that AI can reduce administrative delays in prior authorization, but it must be paired with oversight to ensure patient safety.
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Treatment Pathways: When Chemotherapy Alone Is the Right Choice in Metastatic SCAC
July 11th 2025A panelist discusses how given PODIUM-303's benefits across all subgroups, the primary patient population that should receive chemotherapy alone rather than the combination with retifanlimab would be those with contraindications to checkpoint inhibitors, specifically patients with autoimmune diseases such as irritable bowel disease, organ transplant recipients or those with severe rheumatoid arthritis requiring immunosuppressants, where the risks of checkpoint inhibitor administration outweigh potential benefits, while noting that no validated biomarker currently exists to exclude patients from retifanlimab treatment.
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Comorbidities and Unmet Needs Associated With Vitiligo
July 11th 2025An expert discusses how vitiligo patients commonly develop thyroid disease as a comorbidity and face increased skin cancer risk while highlighting the urgent need for new treatments beyond the single FDA-approved ruxalitinib cream to prevent disease spread and reduce reliance on problematic steroids.
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Impact of Vitiligo on Quality of Life
July 11th 2025An expert discusses how vitiligo significantly affects patients’ psychosocial health due to its visible nature, unpredictable course, slow treatment response, and particularly severe impact on younger patients and those with darker skin tones who may experience depression and social isolation.
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Evidence-Informed Decisions in SCAC Care: Subgroup Insights From POD1UM-303
July 11th 2025A panelist discusses how the POD1UM-303 trial showed that no patient subpopulation was clearly excluded from benefiting from retifanlimab plus carboplatin/paclitaxel in terms of progression-free survival, though PD-L1-negative patients (representing only 10% of the study population) demonstrated a less robust overall survival signal compared to their positive progression-free survival benefit, suggesting that while PD-L1 status is not a validated exclusion biomarker, further research is needed to better understand the optimal benefit in PD-L1-negative patients given prior data showing lower response rates with PD-1 inhibitors in this subgroup.
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Digitizing Prior Authorization Could Ease Burden on Patients and Providers
July 10th 2025In an interview with Managed Healthcare Executive, Yosi Health CEO Hari Prasad praised insurers' new voluntary pledge to simplify prior authorization, calling it a key step toward faster care and reduced administrative burdens for providers and patients.
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The Complex Relationship Between Alcohol, Women, Their Periods and Middle Age
July 9th 2025Period-induced alcohol cravings and societal changes are contributing to a rising trend in women drinking, according to new research from Sarah McKetta, M.D., Ph.D., assistant professor, Mailman School of Public Health, Columbia University and Layne Robinson, clinical psychology doctoral student and graduate research assistant in the RISK Laboratory, University of Kentucky.
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Can the Rural Fund Improve Access Amid Medicaid Cuts?
July 9th 2025Michael Abrams, M.A., managing partner at Numerof & Associates, warned that without clear eligibility rules, the new $50 billion rural hospital relief fund could end up helping the wrong providers instead of the rural hospitals most in need.
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