Disease management of the future promises more remote health monitoring
March 1st 2005WHEN HUMANS WALKED on the moon during the Apollo era, visionaries were foretelling the development of colonies in outer space. Meanwhile, Earthbound communities experienced explosive growth, producing the modern suburb with its housing developments and urban sprawl.
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You don't have to be in the healthcare industry for long before it becomes obvious that change is the only constant. Late in 2004, Christopher Koller conducted an interview with MANAGED HEALTHCARE EXECUTIVE and talked about his job as CEO of Providence-based Neighborhood Health Plan of Rhode Island (NHPRI), which was created in 1993 by the state's 14 Community Health Centers.
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States have limited role in regulating MA organizations
March 1st 2005LAST FALL, THE CENTERS for Medicare and Medicaid Services (CMS) and the National Association of Insurance Commissioners (NAIC), published a memorandum providing guidance to state regulators regarding the licensure and regulation of Medicare Advantage (MA) organizations.
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Standing on the shoulders of giants
March 1st 2005EVERY SO OFTEN, something in healthcare really captures my imagination. I am frequently amazed by the innovation, intelligence and dedication of the people who work in this industry, but once in a while something special will happen and I'll think, "I'm going to remember this for the rest of my life."
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Cilansetron: A novel 5-HT3 receptor antagonist for the treatment of irritable bowel syndrome
February 1st 2005If approved, cilansetron (Calmactin, Solvay Pharmaceuticals) would be the second selective 5-HT3 antagonist introduced for the treatment of irritable bowel syndrome (IBS). Based on 2 main clinical trials, cilansetron 2 mg orally 3 times daily appears to be effective in the relief of IBS-D symptoms (abdominal pain/discomfort) and abnormal bowel habits in both male and female patients. Adverse effects were minor, with constipation being the most commonly reported adverse effect. No information is currently available on cilansetron's potential for drug interactions, need for dose adjustments in renal or hepatic insufficiency, long-term safety, or cost. Cilansetron was granted priority review status by FDA on September 1, 2004, for the treatment of diarrhea-predominant IBS in men and women. Currently marketed agents for the treatment of IBS are only approved for use in female patients.
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Update on the treatment of benign prostatic hyperplasia
February 1st 2005Benign prostatic hyperplasia (BPH) is a common chronic disease, with the incidence of BPH increasing with age. Histopathologic features are present in almost half of all men aged >60 years. The disease can have a profoundly negative impact on patients' quality of life, often causing them to limit or avoid basic activities of daily living. Many patients who develop BPH will seek treatment for bothersome lower urinary tract symptoms (LUTS).
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As George Bernard Shaw once said, "Nothing is ever done in this world until men are prepared to kill one another if it is not done." While accidental fatalities, even those caused by preventable mistakes and human errors, are a far cry from murder, Don Berwick, MD, has seen enough death. He's also heard enough rhetoric about ways to improve healthcare quality.
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Clinical news updates from the 2004 AHA Scientific Sessions
January 1st 2005The American Heart Association (AHA) Scientific Sessions comprise the largest meeting of its kind held in the cardiovascular field, with several thousand presentations given each year. The recently concluded 2004 AHA Scientific Sessions, which took place in New Orleans, included presentations of trials that evaluated potential therapeutic compounds, as well as widely used and accepted compounds in new dosages or combinations, for the treatment of cardiovascular disorders. The compilation of clinical news that follows focuses on the cardiovascular pharmacotherapy trials of greatest interest to formulary decision-makers, including: CREATE, PEACE, A-HeFT, PROTECT, CLEAR Platelets, DIPOM, GEMINI, SHIELD, and RIO-NA.
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Focus on posaconazole: A novel triazole antifungal for the treatment of invasive fungal infections
January 1st 2005Serious infections due to the Aspergillus and Candida species and other filamentous fungi have emerged as an increasing cause of infectious morbidity and mortality in the United States and globally. The most notable explanation for this increase is a rise in the number of immunocompromised patients due to advances in transplantation, the emergence and prevalence of Acquired Immunodeficiency Syndrome (AIDS), and an increase in the number of invasive surgical procedures. 1-3 Treatment of these infections with currently available standard antifungal agents such as amphotericin B, itraconazole, and fluconazole still results in an unacceptably high associated mortality. 3. Furthermore, many of these antifungal agents have limitations, including dose-limiting toxicity, drug-drug interactions, and fungal resistance. 4-10
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