Tibolone reduces fracture and breast CA risk, increases stroke risk
October 14th 2008The Long-Term Intervention on Fractures with Tibolone (LIFT) study demonstrated a reduced risk of vertebral fracture, breast cancer, and possibly colon cancer but a significantly increased risk of stroke in older postmenopausal women treated with tibolone versus those treated with placebo.
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Case of PML reported in efalizumab-treated patient
October 14th 2008Genentech informed healthcare professionals that a 70-year-old patient who has been treated with efalizumab (Raptiva) for chronic psoriasis for >4 years has developed progressive multifocal leukoencephalopathy (PML), a rare, progressive disease of the central nervous system that is usually fatal.
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Tiotropium improves long-term lung function in COPD
October 14th 2008In the Understanding Potential Long-Term Impacts on Function with Tiotropium (UPLIFT) trial, tiotropium therapy for patients with chronic obstructive pulmonary disease (COPD) was associated with long-term improvements in lung function, quality of life, and COPD exacerbations. The therapy did not, however, significantly reduce the rate of decline in forced expiratory volume in 1 second (FEV1) compared with placebo.
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Congress to consider changes to Medicare Part D drug plans
October 1st 2008Even though the Medicare prescription drug benefit has provided access to medications at less-than-anticipated cost to the government-and lower out-of-pocket spending for seniors-many Democrats and consumer advocates want to overhaul the program. Critics contend that the federal government can negotiate prices with pharmaceutical companies that are lower than those obtained by private insurers operating prescription drug plans (PDPs), and some reformers charge that the program is too complex and confusing for elderly beneficiaries, pointing particularly to the infamous "donut hole" that is affecting more Medicare patients than anticipated.
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ARBs demonstrate no beneficial effect on mortality in patients with heart failure
October 1st 2008A systematic search of the literature published in the International Journal of Clinical Practice demonstrated that angiotensin receptor blockers (ARBs) used as monotherapy or in combination with angiotensin-converting enzyme (ACE) inhibitors are not associated with a beneficial effect on mortality in patients with heart failure (HF).
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Ipratropium associated with increased risk of death in patients with COPD
October 1st 2008A nested case-control analysis published in the Annals of Internal Medicine demonstrated an increased risk of all-cause and cardiovascular mortality among patients with recently diagnosed chronic obstructive pulmonary disease (COPD) treated with ipratropium.
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Eltrombopag: A TPO receptor agonist for the treatment of chronic idiopathic thrombocytopenic purpura
October 1st 2008Eltrombopag is a TPO receptor agonist that is currently pending FDA approval for the treatment of ITP. This agent has been granted orphan drug and priority review status. In May 2008, the Oncology Drugs Advisory Committee unanimously agreed that eltrombopag demonstrates a favorable risk:benefit profile for the short-term treatment of chronic ITP.
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What are Analytics? An overused word, an underused resource
October 1st 2008If there was a way to accurately and consistently predict which patients were likely to use the emergency room in the upcoming year or incur a preventable chronic disease in the next 10 years, how would such a capability impact patient care?
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Value propositions for community health information exchange include many voices but one vision
October 1st 2008A successful health information exchange (HIE) must be constructed in a manner that accounts for and serves the needs of each stakeholder group individually and allows all, to share in the benefit. As a result, the success of a community-based HIE is as much a feat of cooperation as it is one of organization.
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Stiff policies applied to Part D marketing
October 1st 2008Many brochures and ads issued by health plans to promote Medicare drug benefits to seniors fail to meet standards. Centers for Medicare and Medicaid Services seeks to stem the criticism by tightening up the rules governing such marketing plans.
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Interactive media signals shift to consumer empowerment
October 1st 2008Stakeholders are all over the communications map trying to reach their audiences in the high-tech world where they live. Whether they're texting consumers, sending e-cards, creating video games or sharing information via social media, all are working to get the healthcare message out.
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