New meta-analysis argues against a link between ARB use and increased cancer risk
March 25th 2011The use of angiotensin-receptor blockers alone are not associated with increased odds of cancer or cancer-related death, according to a meta-analysis published in a recent edition of Lancet Oncology.
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FDA, EMA announce pilot for parallel assessment of Quality by Design applications
March 25th 2011FDA and the European Medicines Agency have launched a new pilot program that will allow parallel evaluation of relevant development and manufacturing data components, known as Quality by Design, of new drug marketing applications that are submitted to both agencies.
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Resistance testing should guide initial treatment choice in HIV
March 18th 2011A substantial portion of antiretroviral-naïve patients are infected with transmitted drug-resistant HIV with one or more drug-resistant mutations, and they are much more likely to experience treatment failure, according to research published in The Lancet Infectious Diseases.
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Anti-tumor necrosis factor-α effective in psoriatic arthritis
March 18th 2011Patients with psoriatic arthritis undergoing their first treatment with tumor necrosis factor-? inhibitor showed a high adherence to therapy and a good response, according to a recent Danish study published in Arthritis & Rheumatism.
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Low literacy predicts nonadherence to medication regimens
March 18th 2011Many patients, especially those with limited literacy, do not consolidate prescription medication regimens efficiently, which could lead to nonadherence, according to a recent study in the Archives of Internal Medicine.
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Both benefits and adverse effects influence elderly's adherence to cardiovascular medication
March 18th 2011The willingness of the elderly to take medication for primary cardiovascular disease prevention is relatively insensitive to its benefit but highly sensitive to its adverse effects, according to a recent study published in the Archives of Internal Medicine.
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XLHealth optimistic about special needs plans
March 15th 2011XLHealth, a Baltimore-based provider of health plan solutions for Medicare beneficiaries with special needs, announced the enrollment of its 100,000th member, and it sees room for more growth despite expected Medicare Advantage cuts
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FDA: Monthly liver enzyme tests no longer needed for PAH drug
March 11th 2011FDA has approved a change to the prescribing information for ambrisentan 5-mg and 10-mg tablets (Letairis, Gilead Sciences) once-daily treatment to improve exercise ability and delay clinical worsening in patients with pulmonary arterial hypertension (PAH, WHO Group 1) and predominantly WHO Functional Class II-III symptoms.
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Coadministration of flu, pneumococcal vaccine increases febrile seizure risk
March 11th 2011Children aged 6 to 23 months who receive trivalent inactivated flu vaccine concurrently with the 13-valent pneumococcal conjugate vaccine are at increased risk of febrile seizures, according to researchers at the Centers for Disease Control and Prevention in Atlanta and Harvard Medical School in Boston.
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Bevacizumab implicated in treatment-related death in cancer patients
March 11th 2011The angiogenesis inhibitor bevacizumab, used with chemotherapy or biological therapy, carries an increased risk of treatment-related death in cancer patients compared with chemotherapy alone, a new study shows.
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Labeling change for antipsychotic drugs highlights risk to newborns
March 11th 2011FDA has updated the pregnancy section of drug labels for the entire class of antipsychotic medications to provide more information about the potential risk of extrapyramidal signs and withdrawal symptoms in newborns whose mothers take antipsychotics during the third trimester of pregnancy.
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FDA advisory committee recommends approval of once-daily bronchodilator for COPD
March 9th 2011FDA's Pulmonary-Allergy Drugs Advisory Committee voted to approve Novartis' QAB149 (indacaterol) 75 µg as a once-daily long-term maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease, including chronic bronchitis and/or emphysema, PR Newswire reported.
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