ASCO: Second-line treatment with ramucirumab with standard docetaxel extends survival in NSCLC
June 5th 2014Ramucirumab (Cyramza) combined with docetaxel (Taxotere) extended overall survival 1.4 months in patients with non-small cell lung cancer (NSCLC) when compared to standard second-line therapy (Taxotere alone), according to data presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.
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ASCO: Bortezomib-based regimen shows improved outcomes for mantle cell lymphoma
June 4th 2014A bortezomib (Velcade)-based regimen significantly improved progression free survival (PFS) and consistently improved secondary efficacy end points in previously untreated mantle cell lymphoma (MCL) patients compared to standard therapy, according to data presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.
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ASCO: Ceritinib shrank tumors in most patients with ALK+ NSCLC regardless of prior ALK treatment
June 4th 2014Ceritinib (Zykadia) previously known as LDK378,shrank tumors in patients with anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC), including those who had received previous treatment with an ALK inhibitor as well as patients receiving one for the first time, according to data presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago. Results were also observed in patients with ALK+ NSCLC who entered the study with brain metastases.
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Delay in filling clopidogrel prescription after coronary stent linked to adverse clinical outcomes
June 3rd 2014A delay in filling the first prescription for clopidogrel after coronary stenting is associated with an increased risk of death and myocardial infarction (MI), according to a study published online May 28 in the Journal of the American Heart Association.
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[BLOG]: Effective collaboration can help to mitigate drug shortages
June 2nd 2014Patients across the country continue to feel the impact of critical prescription drug shortages. As formulary managers understand, an integrated approach to solving shortages, involving all supply chain stakeholders, can have a profound effect on mitigating the impact of shortages on patients.
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BLOG: The goal of vaccines: It’s worth a shot
June 2nd 2014When vaccines eradicate illnesses (eg, smallpox), life is grand. However, when eradication is impossible (eg, pneumococcus), what is the goal of vaccination? The most essential vaccine function is to reduce the number and/or severity of infections.
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MERS, an interferon/innate immune deficiency state, continues to surge
June 2nd 2014The Middle East respiratory syndrome (MERS) is an infectious viral disease with about 30% mortality caused by viral pneumonia and associated lung damage. The etiologic agent of MERS, MERS-CoV, is a member of the coronavirus family. Coronaviruses are responsible for a variety of pathologic effects in a broad spectrum of vertebrates including the virus currently responsible for epidemic piglet deaths in hog farms in the United States. The pathogenicity of MERS is due, in part, to the innate immune deficiency state that results from inhibition of a first responder to viral infection, interferon (IFN).
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FDA approves panitumumab plus FOLFOX for wild-type KRAS metastatic colorectal cancer
June 1st 2014FDA has approved panitumumab (Vectibix, Amgen) for use in combination with FOLFOX, an oxaliplatin-based chemotherapy regimen, as first-line treatment in patients with wild-type KRAS (exon 2) metastatic colorectal cancer (mCRC).
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FDA approves new IV antibacterial drug used to treat adults with skin infections
May 27th 2014FDA has approved dalbavancin (Dalvance, Durata Therapeutics) for injection for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
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Investigational drug in phase 3 study has potential to be first DMARD for knee osteoarthritis
May 27th 2014With global disability concerns rising, Voltarra Pharmaceuticals, Inc. and Menzies Research Institute at the University of Tasmania in Hobart, Australia, have initiated a phase 3, randomized multicenter clinical trial to assess the efficacy and safety of VOLT01 for controlling knee osteoarthritis (OA).
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Botulinum toxin injection may ward off postop AFib
May 24th 2014Injecting botulinum toxin injection into the epicardial fat pads prevented recurrences of atrial tachyarrhythmia in the postoperative period in patients with prior paroxysmal atrial fibrillation (PAF) undergoing coronary artery bypass grafting (CABG) surgery, according to results of a study presented at the Heart Rhythm Society meeting in San Francisco.
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Patients with advanced non-small cell lung cancer (NSCLC) whose tumors have the most common epidermal growth factor receptor (EGFR) mutation (exon 19 deletion) lived longer if treated with first-line afatinib (Gilotrif) compared to chemotherapy, according to data presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO), in Chicago.
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Pirfenidone reduces disease progression of IPF
May 23rd 2014Pirfenidone (Esbriet), an oral antifibrotic therapy, was able to reduce progression of idiopathic pulmonary fibrosis (IPF) and reduce the risk of mortality, according to phase 3 trial results presented at the American Thoracic Society International Conference in San Diego.
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