If approved, tipranavir (Boehringer Ingelheim) will be the ninth protease inhibitor (PI) available and the first nonpeptidic PI available in the United States. Designed by structure-based analysis, tipranavir is more flexible at the binding site, allowing for a potent and durable antiretroviral response. The tipranavir (TPV) and ritonavir (RTV) PI regimen (TPV/r) studied in clinical trials had a moderate pill burden, requiring 4 pills to be taken twice daily (2 RTV 100 mg and 2 TPV 250 mg).
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A timely transition to insulin: Identifying type 2 diabetes patients failing oral therapy
April 1st 2005Although oral antidiabetic medications initially may be effective for controlling hyperglycemia, these agents often fail to maintain adequate glycemic control as the disease progresses, and insulin eventually is required in most patients. This review explores strategies for identifying patients with type 2 diabetes who are failing to maintain glycemic control on oral agents and for transitioning these patients to insulin. Based on available data, patients are not reaching recommended glycemic goals due to delays in and reluctance towards intensification of therapy, resulting in an increased risk of complications.
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At first glance, you might wonder what the Japanese auto industry has to do with managed healthcare in the United States. For Anthony Horbal (pictured left), founder and CEO of Erie, Pa.-based Ion Health Inc. and Mike Nelson, Ion Health's president and director, Japanese automakers just might have provided an epiphany.
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Levodopa remains principal treatment for Parkinson's disease
April 1st 2005Parkinson's Disease is a chronic, progressive neurological disorder that occurs when neurons in the part of the brain that controls movement start to degenerate. This leads to a shortage of the neurotransmitter dopamine, causing characteristic movement problems.
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At first glance, you might wonder what the Japanese auto industry has to do with managed healthcare in the United States. For Anthony Horbal (pictured left), founder and CEO of Erie, Pa.-based Ion Health Inc. and Mike Nelson, Ion Health's president and director, Japanese automakers just might have provided an epiphany.
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Innovative programs help Medicaid recipients thrive
April 1st 2005Not long ago, I was talking with a family friend, Jamie, a young, single mom and then Medicaid recipient. We were discussing our families and I had mentioned how busy I was driving my children to and from their many extracurricular activities and social events.
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Ziprasidone (Geodon, Pfizer) and risperidone (Risperdal, Janssen) are equally efficacious in the treatment of patients with acute exacerbation of schizophrenia and schizoaffective disorder, with ziprasidone demonstrating a lower movement disorder burden and less effect on prolactin concentrations and weight than risperidone.
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Exenatide: A novel incretin mimetic hormone for the treatment of type 2 diabetes
March 1st 2005A number of clinical approaches are utilized in managing the overlapping aspects of poor glycemic control in patients with type 2 diabetes. Exenatide (Amylin/Lilly), a novel drug in a new medication class known as the incretin mimetic agents, offers a new mechanism to achieve glycemic control.
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A new dosage strength of the fentanyl transdermal system (Duragesic, Alza) was approved for the management of persistent, moderate-to-severe chronic pain requiring continuous opioid administration for an extended period of time that cannot be managed by other drugs. The new patch will deliver 12 mcg of fentanyl per hour.
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Prior lack of efficacy with etanercept does not predict lack of efficacy with infliximab
March 1st 2005A study conducted by researchers at the University of Wisconsin, Stanford University, and several rheumatology clinics across the United States found that rheumatoid arthritis (RA) patients who do not receive sufficient benefit with etanercept may experience improved disease control by switching to infliximab.
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Ziprasidone (Geodon, Pfizer) and risperidone (Risperdal, Janssen) are equally efficacious in the treatment of patients with acute exacerbation of schizophrenia and schizoaffective disorder, with ziprasidone demonstrating a lower movement disorder burden and less effect on prolactin concentrations and weight than risperidone.
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ACE inhibitors that penetrate the blood-brain barrier may slow Alzheimer's progress
March 1st 2005Researchers have found that angiotensin-converting enzyme (ACE) inhibitors that penetrate the blood-brain barrier (BBB) appear to reduce the incidence of Alzheimer's disease (AD) in elderly patients with hypertension.
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