California court: Wyeth accountable for harms caused by generic metoclopramide
November 13th 2008On November 7, the First District Court of Appeal in San Francisco, California, overturned a previous ruling in the case of Conte v Wyeth and ruled that Wyeth, the manufacturer of Reglan (metoclopramide), should be held responsible for harm caused to Elizabeth Conte, who developed tardive dyskinesia after taking generic metoclopramide for nearly 4 years. The court upheld the previous ruling in favor of Purepac, Pliva, and Teva, manufacturers of generic metoclopramide.
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Pneumonia mortality rates lower for statin users
November 13th 2008In a large, population-based cohort study published in the Archives of Internal Medicine, current use of statins by patients hospitalized with pneumonia was associated with a decreased risk of death after hospital admission compared with nonusers of statins.
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Metformin moderately protective against CV risk in type 2 diabetics
November 13th 2008Compared with biguanides, thiazolidinediones, meglitinides, and second-generation sulfonylureas, metformin is the sole oral therapy associated with a decreased risk of cardiovascular (CV) mortality in patients with type 2 diabetes, according to a meta-analysis published in the Archives of Internal Medicine.
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Diabetes treatment becoming more complex, more expensive
November 13th 2008In a survey of trends in diabetes treatment from 1994 to 2007, investigators observed an increasing incidence of diabetes, a greater variety of drugs and combinations available for treatment, and a marked increase in the annual cost of diabetes medications.
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Pre-emption case of Wyeth v Levine in hands of US Supreme Court
November 13th 2008On November 3, the US Supreme Court heard arguments in the case of Wyeth v Levine; the ultimate decision of the Court on this case may set a precedent on the issue of pre-emption, a tenet that FDA actions regarding drug approvals and medication safety supersede state laws.
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Conflicts of interest under investigation as policies begin to change
November 13th 2008As conflicts of interest between academia and the pharmaceutical industry are again under investigation, several pharmaceutical companies and universities are beginning to change their policies on disclosures and funding.
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Development of rimonabant and CP-945,598 for obesity is discontinued
November 13th 2008One month after Merck announced that the company was discontinuing development of taranabant, an investigational selective blocker of the cannabinoid-1 (CB-1) receptor that was being studied for the treatment of obesity, Sanofi-Aventis and Pfizer announced that they were also halting the development of their investigational CB-1 receptor antagonists (rimonabant and CP-945,598, respectively).
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Conte v Wyeth: Name-brand drug maker accountable for alleged harm caused by generic drug
November 13th 2008On November 7, 2008, a California Intermediate Appellate Court in San Francisco held that the "common-law duty [of Wyeth] to use due care in formulating its product warnings extends to patients whose doctors foreseeably rely on its product information when prescribing metoclopramide, whether the prescription is written for and/or filled with Reglan or its generic equivalent."
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Employers can't afford benefit plans; technology can be key
November 4th 2008More than one-third of small employers don't offer benefit plans because it is too expensive, according to Mercer. Technology can be the key to making healthcare affordable for all by reducing the cost of delivering care.
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Uninsured crowding ERs lacks evidence
November 4th 2008Lack of access to care has nothing to do with insurance status. A study the Robert Wood Johnson Foundation finds that there is no evidence that, despite perceptions, uninsured adults are primarily responsible for overcrowding in ERs or are using ERs to seek treatment for minor illnesses.
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Medicare and health IT not addressed by candidates
November 4th 2008The candidates are generally in agreement that the next administration should work toward reducing healthcare costs, delivering high-quality patient care, placing an increased emphasis on prevention, and providing coverage for an estimated 46 million uninsured Americans, but their proposals differ dramatically.
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