Kimber Simmons, MD, MS, discusses how type 1 diabetes is a progressive autoimmune disease requiring early identification through autoantibody screening and C-peptide monitoring, with management approaches evolving from reactive insulin replacement toward proactive immunomodulation and beta cell preservation strategies that can alter disease trajectory and improve outcomes.
EP. 1: Type 1 Diabetes: Understanding Disease Progression and Beta Cell Function
March 28th 2025A panelist discusses how type 1 diabetes (T1D) is a complex autoimmune disease characterized by progressive beta cell destruction that advances through distinct stages, with genetic predisposition, environmental triggers and the presence of specific autoantibodies serving as key risk factors and diagnostic markers.
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EP. 2: C-Peptide and Early Type 1 Diabetes Detection
April 4th 2025A panelist discusses how C-peptide serves as a critical biomarker of endogenous insulin production, providing clinicians with valuable insights into remaining beta cell function that can guide personalized treatment approaches and help predict disease progression in patients with type 1 diabetes (T1D).
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EP. 3: Advancing Early Detection: Autoimmune Screening in Type 1 Diabetes
April 11th 2025A panelist discusses how autoimmune screening through detection of diabetes-specific autoantibodies serves as a critical tool for identifying pre-symptomatic type 1 diabetes (T1D), enabling earlier intervention before significant beta cell loss occurs and potentially changing the disease trajectory through timely management strategies.
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