Cemiplimab Monotherapy and Five-Year Outcomes in Advanced Non-Small Cell Lung Cancer: Results and Implications
Eric K. Singhi, M.D.,and Ben Creelan, M.D., discuss how over the past 5 years, PD-1 inhibitors have reshaped first-line therapy for advanced non-small cell lung cancer (NSCLC), improving survival outcomes. Biomarkers like PD-L1 and patient characteristics guide treatment choices. New data on cemiplimab enhances decision-making, balancing efficacy with quality of life.
EP. 1: Setting the Stage: Immunotherapy’s Impact and EMPOWER-Lung 1 Study Design
March 28th 2025Panelists discuss how over the last five years, immunotherapy, particularly PD-1 inhibitors, has revolutionized advanced non-small cell lung cancer (NSCLC) treatment, offering promising first-line therapy options. Prior to the EMPOWER-Lung 1 study, PD-1 inhibitors showed improved survival outcomes as monotherapy. Treatment considerations have since evolved to incorporate patient-specific factors, optimizing therapy based on individual characteristics.
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EP. 2: Optimizing First-Line and Sequential Therapy in Advanced NSCLC
March 28th 2025Panelists discuss how biomarkers like PD-L1 guide first-line therapy in advanced non-small cell lung cancer (NSCLC), with higher expression favoring PD-1 inhibitors. Other factors like performance status and comorbidities also support their use. Post progression, PD-1 inhibitors are often used alone or in combination for subsequent lines of treatment.
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