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Biomarkers for Graft-Versus-Host Disease | Part 2
Biomarkers can be used for many purposes — diagnosis, prognosis, projections for success of a treatment. Sophie Paczesny, M.D., Ph.D., a professor at the Hollings Cancer Center at the Medical University of South Carolina and an internationally recognized expert on biomarkers for graft-versus-host disease (GvHD), reviews a typology of biomarkers that groups them into five subtypes and discusses their use in GVHD.
Second of four parts
Graft-versus-host disease (GvHD) is a side effect of allogeneic hematopoietic cell transplantation used to treat many types of blood cancers (leukemia, multiple myeloma) and other conditions related to the blood and the blood marrow. In simplified terms, GvHD occurs when the immune cells in the transplant (“the graft”) turn on and attack the cells of the recipient (“the host.”)
In a review article published in Transplantation and Cellular Therapy in July, corresponding author Sophie Paczesny, M.D., Ph.D., and her colleagues gave an overview of biomarkers and their application to GvHD. Paczesny, a professor and chair of the Department of Microbiology and Immunology at the Hollings Cancer Center at the Medical of University of South Carolina, is an expert on hematopoietic cell transplantation, GvHD and biomarkers.
In this segment, Paczesny reviews a National Institutes of Health-FDA typology for biomarkers that includes five functional subtypes — diagnostic, predictive, response (a measurement of how a patient is responding to a treatment), prognostic and risk (a biomarker that show the potential someone has for developing a condition prior to having symptoms).
In the review article, Paczesny and her colleagues discuss research into these subtypes of biomarkers for GvHD, delineating them for both acute and chronic GvHD.
2023 Drug Trend Report - Xevant
May 16th 2024To effectively navigate the changing pharmacy landscape and maintain a robust, cost-effective pharmacy benefit, you must understand the forces behind rising drug trend. What’s driving your costs and what can you do about it? As a leader in the PBM analytics space, we offer a unique perspective on pivotal trend drivers. Here’s what our comprehensive analysis revealed: -A surge in utilization rates across specialty and non-specialty drugs, magnified by anti-obesity therapies -Financial strain imposed by anti-inflammatory biologics and the yet-to-be-fulfilled -promise of biosimilar savings -Persistent price inflation driving higher costs year over year
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